Ciclopirox Olamine USP/ EP (Kopcyclamine)
chemicals & pharmaceuticals
Ciclopirox Olamine is a synthetic broad spectrum antifungal agent that inhibits the growth of pathogenic dermatophytes, yeasts and malassezia furfur. Ciclopirox Olamine exhibits fungicidal activity in-vitro against isolates of Trichopython rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis and Candida albicans. It is presumed that Ciclopirox Olamine mediated growth inhibition or death offungal cells is primarily caused by in-vitro cellular depletion of some essential substrates or ions and that such effects are brought about through blockage of their uptake from the medium. It also has anti-inflammatory activity. The FDA has approved this compound for use in the US in Dec 1999 Application: Cream 0.77%– Treatment of tinea pedis (Athelete’s foot), Tinea Cruris(Jock Itch), Tinea Corporis (Ringworm), Cutaneous Candidiasis and Tinea Versicolor (Pityriasis) Gel 0.77%– Treatment of Tinea pedis (Athelete’s foot), Tinea Corporis (Ringworm), Seborrheic Dermatitis of the scalp. Lacquer 8%– Topical treatment of mild to moderate onychomycocis of the fingernails and toenails due to Trichophyton rubrum. Shampoo 1% – Treatment of Seborrheic Dermatitis, formation of scales and flakes on the scalp.
